Observer-masked trial comparing efficacy of topical olopatadine (0.1%), bepotastine (1.5%), and alcaftadine (0.25%) in mild to moderate allergic conjunctivitis

Purpose: With increasing environmental pollution, the incidence of allergic conjunctivitis is increasing. Newer anti-allergic medications with combined anti-histaminic and mast cell stabilization action can help reducing the use of topical steroids for milder form of disease. There is no study directly comparing olopatadine (0.1%), bepotastine (1.5%), and alcaftadine (0.25%) for mild to moderate allergic conjunctivitis cases. Hence, we decided to methodically study the efficacy of three topical medications. Methods: Prospective, observer-masked clinical trial enrolled 45 patients with 15 patients in each of the three groups. Patients with mild to moderate allergic conjunctivitis were sequentially assigned to respective groups, and relief of symptoms and signs were noted upto 1-month follow-up. Results: All three topical medications faired almost equally in resolving symptoms of the patients with mild to moderate allergic conjunctivitis, and most of them reported complete relief after 1 week of use of medication. Few cases with limbal or palpebral papillae reported symptomatic relief after use of medication, but the resolution of these signs was not noted in all three groups. Conclusion: We concluded similar efficacy of three medications in relieving symptoms and inefficacy in regressing palpebral and limbal papillae in cases of allergic conjunctivitis.

Studies on the zooplankton biodiversity and density in Adyar estuary, Chennai, India.

The Adyar estuary was once known for its unique ecology and endemic flora and fauna, has lost its pristine condition due to urbanization, discharge of untreated domestic wastes, industrial effluents and encroachments. Zooplankton were monitored for a period of one year from July 2009 to June 2010, following standard methods to evaluate the seasonal variations in diversity and density in relation to environmental parameters like temperature (28.6-33.6ºC), salinity (23.3-30.3‰), pH (7.3-7.8) and DO (4.4-7.1mg l-1). Highest diversity was observed during post-monsoon (20 species) and pre-monsoon (19 species), followed by summer (9 species) and monsoon (9 species). The zooplankton density was maximum during summer (1887167 m-3) followed by pre-monsoon (1843832 m-3), post-monsoon (1153333 m-3) and monsoon (182334 m-3). Zooplankton community structure and dynamics showed a differential pattern with dominance of harpacticoids and rotifers in pre-monsoon; cyclopoids and rotifers during post-monsoon and summer. The significance of monitoring zooplankton biodiversity as a base-line study for future investigations on environmental changes in this area is discussed.